Zaak, Dirk and Hungerhuber, Edwin and Schneede, Peter and Stepp, Herbert and Frimberger, Dominic and Corvin, Stefan and Schmeller, Nikolaus and Kriegmair, Martin and Hofstetter, Alfons and Knoechel, Ruth (2002) Role of 5-aminolevulinic acid in the detection of urothelial premalignant lesions. CANCER, 95 (6). pp. 1234-1238. ISSN 0008-543X, 1097-0142
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND. The authors evaluated the role of 5-aminolevulinic acid (5-ALA)induced fluorescence endoscopy (AFE) in the detection of flat urothelial lesions in light of the suggestions made for flat neoplastic lesions within the 1999 World Health Organization (WHO) classification of urinary bladder tumors. METHODS. From 1995 to 2000, 713 patients underwent 1414 AFE procedures for the detection of transitional cell carcinoma of the bladder (TCCB). Fluorescence imaging was performed with an incoherent light source (D-light; 380-440 nm) that was filtered for efficient protoporphyrin IX excitation and with cystoscopes partially blocking reflected excitation light to enable fluorescence evaluation by a red/blue color contrast 2-3 hours after 50 mL of a 3% solution of 5-ALA was instilled into the bladder. In total, 3834 biopsy specimens (mean, 2.7 specimens per AFE procedure) were taken. RESULTS. Malignant disease was found in 1250 (32.6%) of all biopsies, with 304 biopsies (24.3%) showing carcinoma in situ (cis) and dysplasia IIdegrees (dys II) according to the previous diagnostic criteria of the WHO. Under prior conventional white-light endoscopy, 30.3% of specimens with dys II and 52.8% of specimens with cis had been missed. CONCLUSIONS. The current results suggest that 5-ALA may be more effective in the detection of flat urothelial lesions than the current diagnostic devices. (C) 2002 American Cancer Society.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; BLADDER-CANCER; URINARY CYTOLOGY; FLUORESCENCE; BIOPSIES; 5-aminolevulinic acid; fluorescence; bladder carcinoma; dysplasia; carcinoma in situ |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Oct 2021 15:09 |
| Last Modified: | 06 Oct 2021 15:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39872 |
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