Bürgermeister, Jutta and Paper, Dietrich H. and Vogl, Horst and Linhardt, Robert J. and Franz, Gerhard (2002) LaPSvS1, a (1 -> 3)-beta-galactan sulfate and its effect on angiogenesis in vivo and in vitro. CARBOHYDRATE RESEARCH, 337 (16). pp. 1459-1466. ISSN 0008-6215
Full text not available from this repository.Abstract
LaPSvS1, a highly sulfated branched (1 --> 3)-beta-galactan was prepared from the arabino-galactan from Larix decidua Miller by partial hydrolysis and subsequent sulfation with SO3-pyridine in DMF. The molecular weight was analyzed by GPC and the sulfate content was determined by ion chromatography. LaPSvS1 exhibited good antiangiogenic and antiinflammatory effects in two different modifications of the known CAM-assay. In vitro results obtained in the FGF-2-trypsin-assay and in fluorospectrometric experiments revealed that LaPSvS1 interacts with the fibroblast growth factor 2 system. This interaction is correlated with the in vivo effect of LaPSvS1 on FGF-2 induced angiogenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FIBROBLAST-GROWTH-FACTOR; BINDING; GLYCOSAMINOGLYCANS; INHIBITORS; AFFINITY; ASSAYS; angiogenesis inhibitor; antiinflammatory; CAM-assay; FGF-2; (1 -> 3)-beta-galactan-sulfate |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Franz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Sep 2021 09:58 |
| Last Modified: | 01 Sep 2021 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39876 |
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