Pihusch, R. and Holler, E. and Muhlbayer, D. and Gohring, P. and Stoetzer, O. and Pihusch, M. and Hiller, E. and Kolb, H. J. (2002) The impact of antithymocyte globulin on short-term toxicity after allogeneic stem cell transplantation. BONE MARROW TRANSPLANTATION, 30 (6). pp. 347-354. ISSN 0268-3369
Full text not available from this repository.Abstract
Antithymocyte globulin (ATG) is commonly used in allogeneic haematopoietic stem cell transplantation (HSCT). Little information is available, however, as to the optimal protocol for use and the side-effects occurring if ATG is administered in high daily doses (10-30 mg/kg). We report our experience with ATG Fresenius (ATG-F) in conditioning for allogeneic HSCT. During a period of 3 days, 47 patients received doses between 10 and 30 mg/kg either over 4 h preceded by 1-1.5 mg/kg prednisolone 30 min before the start of ATG-F (protocol A) or alternatively, over 12 h with 3-4 mg/kg prednisolone being administered before and 6 h after start of ATG (protocol B). During treatment with ATG-F, the side-effects observed included inflammation, disseminated intravascular coagulation, hyperdynamic circulation and renal dysfunction. Although these complications caused substantial morbidity, they were reversible within a few days. Side-effects were significantly more severe in patients treated according to protocol A than in those treated according to protocol B. As prolonged infusion of ATG-F does not reduce T cell clearance due to the long half-life of ATG-F, and since less cytokine release during conditioning might have beneficial long-term effects, we recommend administering ATG-F over 12 h preceded by high-dose steroid treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW TRANSPLANTATION; HOST DISEASE; MONOCLONAL-ANTIBODY; SEPTIC SHOCK; PROCALCITONIN; SERUM; INFECTION; SEPSIS; GRAFT; COAGULATION; antithymocyte globulin; side-effects; treatment; transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Oct 2021 15:20 |
| Last Modified: | 06 Oct 2021 15:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39893 |
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