Lotti, Barbara and Wendland, Thomas and Furrer, Hansjakob and Yawalkar, Nikhil and Greyerz, Salome von and Schnyder, Karin and Brandes, Marlene and Vernazza, Pietro and Wagner, Ralf and Nguyen, Thi and Rosenberg, Eric and Pichler, Werner J. and Brander, Christian (2002) Cytotoxic HIV-1 p55(gag)-specific CD4(+) T cells produce HIV-inhibitory cytokines and chemokines. JOURNAL OF CLINICAL IMMUNOLOGY, 22 (5): UNSP 0271-. pp. 253-262. ISSN 0271-9142
Full text not available from this repository. (Request a copy)Abstract
CD4(+) T-helper cells appear to be essential in sustaining immune responses in chronic viral infections, as the maintenance of CD8(+) cytotoxic T-lymphocyte responses and the control of viremia were demonstrated to depend on CD4(+) T cell help. In order to investigate the function of HIV-specific CD4(+) T cells in chronic HIV-1-infection, 49 chronically HIV-infected patients were analyzed before and 3 and 6 months after initiation of antiviral treatment. Ten patients showed a substantial, although weak, proliferative response to HIV-1-p55(g)ag protein for which no improvement was observed upon initiation of HAART. From one individual, HIV-1-p55(g)ag-specific CD4-positive T-cell clones were generated that were heterogeneous in their TCR Vbeta gene usage and HLA-DRB1*13 and DRB1*03 restricted, respectively. In addition, some CD4(+) TCC produced substantial amounts of IFN-gamma and MIP-1alpha/beta, were perforin-positive, and showed cytotoxic activity. These diverse functional features of HIV-specific CD4(+) T cells suggest that they may exert direct antiviral activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNODEFICIENCY-VIRUS INFECTION; ANTIGEN-PRESENTING CELLS; MEDIATED CYTOTOXICITY; ANTIRETROVIRAL THERAPY; RESPONSES; RECEPTOR; CLONES; LYMPHOCYTES; DISEASE; CD8(+); CD4 T cell; HIV; chemokines; cytotoxic; antiviral activity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Oct 2021 16:16 |
| Last Modified: | 06 Oct 2021 16:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39921 |
Actions (login required)
 |
View Item |
