Hoecherl, Klaus and Kammerl, Martin C. and Schumacher, Karl and Endemann, Dirk and Grobecker, Horst F. and Kurtz, Armin (2002) Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 283 (2). F294-F301. ISSN 1931-857X
Full text not available from this repository. (Request a copy)Abstract
We investigated the effect of cyclooxygenase (COX) activity on the regulation of the renin-angiotensin-aldosterone system by salt intake. Therefore, Sprague-Dawley rats were subjected to different salt diets [0.02, 0.6, and 8% NaCl (wt/wt)] and treated with the selective COX-2 inhibitor rofecoxib (10 mg.kg body wt(-1).day(-1)) or with ketorolac at a dose selective for COX-1 inhibition (2 mg.kg body wt(-1).day(-1)) for 3, 7, 14, and 21 days. Rofecoxib and ketorolac caused a similar reduction of renocortical PGE(2) formation with a low-salt diet. Rofecoxib did not change plasma renin activity or renocortical renin mRNA abundance with any of the diets but clearly lowered plasma aldosterone concentration. In contrast, ketorolac delayed the increase in plasma renin activity and of renin mRNA in response to low salt intake but did not change plasma aldosterone concentration. Prolonged treatment with rofecoxib but not with ketorolac caused an upregulation of COX-2 expression while COX-1 mRNA abundance remained unchanged. These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ASCENDING LIMB CELLS; MACULA DENSA; PROSTAGLANDIN-SYNTHESIS; RAT-KIDNEY; CYCLOOXYGENASE-2 INHIBITION; RENAL PROSTAGLANDINS; STIMULATED RENIN; GENE-EXPRESSION; SODIUM-INTAKE; RELEASE; cyclooxygenase; kidney |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Anatomie Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Oct 2021 09:03 |
| Last Modified: | 11 Oct 2021 09:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39992 |
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