Schroeppel, Bernd and Fischereder, Michael and Ashkar, Rami and Lin, Marvin and Kraemer, Bernhard K. and Marder, Brad and Schiano, Tom and Murphy, Barbara (2002) The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation. AMERICAN JOURNAL OF TRANSPLANTATION, 2 (7). pp. 640-645. ISSN 1600-6135
Full text not available from this repository. (Request a copy)Abstract
Chemokines and their corresponding receptors likely play a central role in directing mononuclear cells to the graft sites during rejection. Genes for the chemokine stromal derived factor-1 (SDF1) and CC chemokine receptors CCR2 and CCR5 are characterized by polymorphisms which alter their function. We genotyped DNA of 207 liver transplant recipients by PCR or PCR-RFLP for CCR2-641, CCR5Delta32, and SDF1-3'A polymorphisms, and examined their association on outcomes in liver allograft recipients. Due to the low number of patients homozygous for CCR2-641 and CCR5Delta32, only the effects of their heterozygous variants were addressed in this study. None of the investigated polymorphisms showed a significant shift in gene frequency in acute rejection and rejection-free groups, or for graft survival. The gene frequency of the SDF1-3'A allele was significantly (p = 0.034) higher in patients who died (29.0%, n = 31) compared to recipients still alive (17.1%, n = 172). The mean patient survival time post transplant was 134 months in patients with SDF1 wild-type, significantly (log rank p = 0.014) longer than 98 months in patients with at least one SDF1-3'A allele. The CCR2 and CCR5 polymorphisms were not associated with significant differences in mortality rate. In conclusion, CCR2-641, CCR5Delta32, and SDF1-3'A genotypes did not influence the risk for acute rejection or graft survival. However, in liver allograft recipients SDF1-3'A is significantly associated with higher mortality.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-DERIVED FACTOR; ALLOGRAFT-REJECTION; CC-CHEMOKINE; GENE POLYMORPHISMS; HIV-1 INFECTION; IN-VITRO; EXPRESSION; RECIPIENTS; VARIANT; DISEASE; CCR2; CCR5; graft survival; rejection; SDF1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Oct 2021 09:08 |
| Last Modified: | 11 Oct 2021 09:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/39993 |
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