Schmitz, Gerd and Kaminski, W. E. (2002) ABCA2: a candidate regulator of neural transmembrane lipid transport. CELLULAR AND MOLECULAR LIFE SCIENCES, 59 (8). pp. 1285-1295. ISSN 1420-682X
Full text not available from this repository.Abstract
Studies in the past years have implicated multispan transmembrane transport molecules of the ATP binding cassette (ABC) transporter family in cellular lipid export processes. The prototypic ABC transporter ABCA1 has recently been demonstrated to act as a major facilitator of cellular cholesterol and phospholipid export. Moreover, the transporter ABCA4 (ABCR) plays a pivotal role in retinaldehyde processing, and ABCA3 has recently implicated in lung surfactant processing. These pioneering observations have directed considerable attention to the A subfamily of ABC proteins. ABCA2 is the codefining member of the ABC A-transporter subclass. Although known for some time, it was not until recently that its complete molecular structure was established. Unlike other ABC A-subfamily members, ABCA2 is predominantly expressed in the brain and neural tissues. The unique expression profile together with available structural data suggest roles for this largest known ABC protein in neural transmembrane lipid export.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATP-BINDING CASSETTE; PROSTAGLANDIN-D-SYNTHASE; DISEASE GENE ABCR; FAMILIAL INTRAHEPATIC CHOLESTASIS; CAUSE PSEUDOXANTHOMA ELASTICUM; STEROL-DEPENDENT REGULATION; RNA TISSUE DISTRIBUTION; APOLIPOPROTEIN-D; TANGIER-DISEASE; MOLECULAR-CLONING; ABC transporter; ABCA2; macrophage; cholesterol; neural lipid transport; neuropathy; myelination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jun 2021 09:34 |
| Last Modified: | 09 Jun 2021 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40002 |
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