Lehmann, Hartwig W. and Kuehner, Lucia and Beckenlehner, Karin and Mueller-Godeffroy, Esther and Heide, Karl-Günter and Kuester, Rolf-Michael and Modrow, Susanne (2002) Chronic human parvovirus B19 infection in rheumatic disease of childhood and adolescence. JOURNAL OF CLINICAL VIROLOGY, 25 (2): PII S1386-. pp. 135-143. ISSN 1386-6532
Full text not available from this repository. (Request a copy)Abstract
Parvovirus B19 causes erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. About 20% of infections are associated with delayed virus elimination and viremia persisting over several months or years. These persistent B19-infections are characterised by the presence of IgG against the non-structural protein NS1. This study aimed to find further evidence for an association of parvovirus B19 persistence with VP1/2- and NS1-specific IgG-antibodies in children suffering from rheumatic diseases of childhood. Forty-eight children and adolescents with joint complaints lasting longer than 1 year including patients with juvenile systemic sclerosis and juvenile dermatomyositis showed antibodies against the viral NS1-protein. Laboratory markers of inflammation, humoral immune response against parvovirus B19 proteins and the presence of viral genomes in patients' sera as well as in 124 healthy children were investigated. Almost 50% of the patients showed laboratory signs of chronic inflammation. B19-DNA was amplified in 31% of patients' sera and 7% of the controls (P<0.0001). VP2-specific IgM was detectable in 50% of the patients' and 6% of control sera. NS1-specific immune reactions were linked to persistent B19-infection as indicated by the presence of viral genomes in the peripheral blood and of VP2-specific IgM years after disease onset. To estimate the severity of the disease and the clinical course, the number of affected and functionally impaired joints were noted and compared with the records from patients' initial visit in the hospital. Disease related complications were registered. Impairment of activities of daily living was assessed by Childhood Health Assessment Questionnaire (CHAQ)- and Munich Quality of Life Questionnaire (KINDL)-tests. During observation the clinical state of four patients worsened, 27 improved, the others remained stable. Twenty-four children were restricted in their daily activities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW; CLINICAL MANIFESTATIONS; NONSTRUCTURAL PROTEIN; BLOOD-DONORS; P6 PROMOTER; DNA; ANTIBODIES; PERSISTENCE; ARTHRITIS; IGG; parvovirus 1319; NS1-protein; juvenile arthritis; viral persistence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2021 06:53 |
| Last Modified: | 12 Oct 2021 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40042 |
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