Straub, Rainer H. and Kittner, Jens M. and Heijnen, Cobi and Schedlowski, Manfred and Schmidt, Reinhold E. and Jacobs, Roland (2002) Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis. JOURNAL OF RHEUMATOLOGY, 29 (8). pp. 1659-1664. ISSN 0315-162X
Full text not available from this repository.Abstract
Objective. To investigate the pituitary and adrenal hormone response after an intravenous epinephrine challenge in patients with rheumatoid arthritis (RA) and controls. Methods. Fifteen untreated female patients with RA (age 51.5 +/- 3.2 yrs) and 7 healthy female controls (48.0 +/- 4.3 yrs) were infused with epinephrine (0.05 mug/kg/min) for about 20 min. Plasma levels of adrenocorticotropic hormone (ACTH), and serum levels of cortisol, 17-hydroxyprogesterone (17OHP), and dehydroepiandrosterone sulfate (DHEAS) were analyzed at baseline and shortly after cessation of epinephrine infusion (20 min). Results. At baseline and after epinephrine infusion, serum levels of cortisol (p = 0.045) and 170HP (p = 0.021) were higher in controls compared to patients with RA. In contrast, at baseline and after epinephrine infusion, plasma levels of ACTH and serum levels of DHEAS were similar in controls and patients. After epinephrine infusion, only the patients with RA had a significant decrease of serum cortisol (p = 0.026) and serum 17OHP (p = 0.026). Plasma levels of ACTH (p = 0.073) and serum levels of DHEAS (p = 0.055) tended to decrease. Conclusion. Serum cortisol and 17OHP (cortisol precursor) were lower in patients with RA compared to controls despite similar ACTH levels. Simulation of an adrenomedullary stress response by epinephrine infusion decreased serum cortisol and 17OHP in patients but not in controls. Such a response may play an unfavorable role during a typical stress reaction in patients with RA that may lead to a more proinflammatory situation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; ACUTE PSYCHOLOGICAL STRESS; NERVOUS-SYSTEM; MESSENGER-RNA; IMMUNE-SYSTEM; CELLS; SECRETION; PROLACTIN; CATECHOLAMINES; MECHANISMS; rheumatoid arthritis; cortisol; epinephrine infusion; adrenocorticotropic hormone; DHEAS; 17-hydroxyprogesterone |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2021 07:03 |
| Last Modified: | 12 Oct 2021 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40046 |
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