Jeschke, Marc G. and Einspanier, Ralf and Klein, Dagmar and Jauch, Karl-Walter (2002) Insulin attenuates the systemic inflammatory response to thermal trauma. MOLECULAR MEDICINE, 8 (8). pp. 443-450. ISSN 1076-1551
Full text not available from this repository. (Request a copy)Abstract
Background: Insulin has been recently shown to decrease mortality and prevent the incidence of multi-organ failure in critically ill patients. The molecular mechanisms by which insulin improves survival have not been defined. The purpose of the present study was to determine the effect of insulin therapy on the systemic inflammatory response. In vivo we determined the effect of insulin therapy on the inflammatory cascade, which was induced by thermal injury. Materials and Methods: Thermally injured rats (30% TBSA) were randomly divided into two groups to receive either saline (n = 28) or insulin (n = 28). Our outcome measures encompassed the effect of insulin on proinflammatory cytokines, anti-inflammatory cytokines, and hepatic signal transcription factor mRNA expression. Results: insulin significantly decreased dose dependently serum pro-inflammatory cytokines IL-1beta at 1, 5, and 7 days, IL-6 at 1 day, MIF at 5 and 7 days, and TNF at I and 2 days after injury when compared with controls (p < 0.05). Insulin increased anti-inflammatory cytokines IL-2 and IL-4 at 5 and 7 days after trauma, and IL-10 at 2, 5 and 7 days after trauma when compared with controls (p < 0.05). Pro-inflammatory signal transcription factors STAT-5 and C/EBP-beta mRNA were significantly decreased 1 and 2 days posttrauma; insulin increased anti-inflammatory signal transcription factor mRNA expression of SOCS-3 and RANTES 7 days after the injury (p < 0.05). Conclusions: Our data provide insight that insulin attenuates the inflammatory response by decreasing the proinflammatory and increasing the anti-inflammatory cascade, thereby restoring systemic homeostasis, which has been shown critical for organ function and survival in critically ill patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE-PHASE RESPONSE; GROWTH-FACTOR-I; TRANSCRIPTIONAL REGULATION; CYTOKINE SYNTHESIS; CRITICAL ILLNESS; HUMAN MONOCYTES; INJURY; HORMONE; SUPPRESSORS; CACHECTIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2021 08:20 |
| Last Modified: | 12 Oct 2021 08:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40056 |
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