Lingohr, Melissa K. and Buettner, Roland and Rhodes, Christopher J. (2002) Pancreatic beta-cell growth and survival - a role in obesity-linked type 2 diabetes? TRENDS IN MOLECULAR MEDICINE, 8 (8). pp. 375-384. ISSN 1471-4914
Full text not available from this repository.Abstract
Obesity-linked type 2 diabetes is a disease of insulin resistance combined with pancreatic beta-cell dysfunction. Although a role for beta-cell mass in the pathogenesis of obesity-linked type 2 diabetes has recently gained prominence, the idea is still being developed. It is proposed that in early obesity an increase in beta-cell mass and function might compensate for peripheral insulin resistance. However, as time and/or the severity of the obesity continue, there is decay in such adaptation and the beta-cell mass becomes inadequate. This, together with beta-cell dysfunction, leads to the onset of type 2 diabetes. It is becoming evident that elements in insulin and insulin growth factor (IGF)-1 signal-transduction pathways are key to regulating beta-cell growth. Current evidence indicates that interference of insulin signaling in obesity contributes to peripheral insulin resistance. This article examines whether a similar interference of IGF-1 signaling in the beta-cell could hinder upregulation of beta-cell mass and/or function, resulting in a failure to compensate for insulin resistance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-RECEPTOR SUBSTRATE-1; ACTIVATED PROTEIN-KINASE; HORMONE-RELATED PROTEIN; TRANSGENIC MICE; FACTOR-I; SIGNAL-TRANSDUCTION; PHOSPHOINOSITIDE 3-KINASE; CHRONIC HYPERGLYCEMIA; LACTOGENIC HORMONES; ISLET HYPERPLASIA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jun 2021 07:34 |
| Last Modified: | 09 Jun 2021 07:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40069 |
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