Wiesenack, Christoph and Wiesner, Gunther and Keyl, Cornelius and Gruber, Michael and Philipp, Alois and Ritzka, Markus and Prasser, Christopher and Taeger, Kai (2002) In vivo uptake and elimination of isoflurane by different membrane oxygenators during cardiopulmonary bypass. ANESTHESIOLOGY, 97 (1). pp. 133-138. ISSN 0003-3022
Full text not available from this repository. (Request a copy)Abstract
Background: Volatile anesthetics are frequently used during cardiopulmonary bypass (CPB) to maintain anesthesia. Uptake and elimination of the volatile agent are dependent on the composition of the oxygenator. This study was designed to evaluate whether the in vivo uptake and elimination of isoflurane differs between microporous membrane oxygenators containing a conventional polypropylene (PPL) membrane and oxygenators with a new poly-(4-methyl-1-pentene) (PMP) membrane measuring isoflurane concentrations in blood. Methods: Twenty-four patients undergoing elective coronary bypass surgery with the aid of CPB were randomly allocated to one of four groups, using either one of two different PPL-membrane oxygenators for CPB or one of two different PMP-membrane oxygenators. During hypothermic CPB, 1% isoflurane in an oxygen-air mixture was added to the oxygenator gas inflow line (gas flow, 3 l/min) for 15 min. Isoflurane concentration was measured in blood and in exhaust gas at the outflow port of the oxygenator. Between-group comparisons were performed for the area under the curve (AUC) during uptake and elimination of the isoflurane blood concentrations, the maximum isoflurane blood concentration (C-max), and the exhausted isoflurane concentration (F-E). Results: The uptake of isoflurane, expressed as AUC of isoflurane blood concentration and a function of F-E, was significantly reduced in PMP oxygenators compared to PPL oxygenators (P < 0.01). C-max was between 8.5 and 13 times lower in the PMP-membrane oxygenator groups compared to the conventional PPL-membrane oxygenator groups (P < 0.01). Conclusions: The uptake of isoflurane into blood via PMP oxygenators during CPB is severely limited. This should be taken into consideration in cases using such devices.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLASMA LEAKAGE; PHARMACOKINETICS; BLOOD; GAS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2021 09:12 |
| Last Modified: | 13 Oct 2021 09:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40095 |
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