Grimm, Daniela and Jabusch, Hans C. and Kossmehl, Peter and Huber, Michaela and Fredersdorf, Sabine and Griese, Daniel P. and Kraemer, Bernhard K. and Kromer, Eckhard P. (2002) Experimental diabetes and left ventricular hypertrophy - Effects of beta-receptor blockade. CARDIOVASCULAR PATHOLOGY, 11 (4): PII S1054-. pp. 229-237. ISSN 1054-8807
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Background: Left ventricular hypertrophy involves growth of cardiomyocytes, as well as remodeling of extracellular matrix proteins (ECMPs). Several metabolic abnormalities may be triggered secondary to hyperglycemia in diabetes. The effects of combined supravalvular aortic banding and diabetes mellitus oil the rat heart were investigated in order to detect possible synergistic effects of these two conditions. Moreover, this study focused on the impact of beta-adrenoceptor blockade with carvedilol (C) on the expression of ECMPs. Methods: Sixty male Wistar rats were allocated to six groups: control (CON), CON + C, streptozotocin (65 mg/kg iv)-induced diabetes (D), D + C, aortic stenosis (AS) + D and AS + D + C. Follow-up was 6 weeks. Results: Relative left ventricular weight was elevated and body weight was decreased in D, AS + D and AS + D + C rats (P<.05 vs. CON). Diabetes elevated cardiomyocyte widths, perivascular/interstitial fibrosis (P<.01 each), as well as ECMPs: collagen I/fibronectin/laminin were 3.4-fold/4. 1-fold/1.5-fold elevated in D rats and further increased (4.6-fold/5.9-fold/1.9-fold) in AS+D rats (P<.01 vs. CON). Heart rate and blood pressure decreased in D and AS+D rats (P<.05 vs. CON). Carvedilol application attenuated the overexpression of ECMPs. Conclusions: Beta-adrenoceptor blockade results in regression of the hypertrophic phenotype and in decrease of ECMP in rats with experimental diabetes and in animals with combined chronic pressure overload and hyperglycemia. These results represent a new mechanism of carvedilol that may contribute to the observed beneficial effects in heart failure. (C) 2002 Elsevier Science Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONVERTING ENZYME-INHIBITION; ACUTE MYOCARDIAL-INFARCTION; PRESSURE-OVERLOAD HYPERTROPHY; RENIN-ANGIOTENSIN SYSTEM; HEART-FAILURE; AORTIC-STENOSIS; CARDIOMYOPATHY; RATS; CARVEDILOL; MELLITUS; beta-adrenoceptor blocker; hypertrophy rats; extracellular matrix |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Oct 2021 11:17 |
| Last Modified: | 18 Oct 2021 11:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40102 |
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