Stanewsky, Ralf (2002) Clock mechanisms in Drosophila. CELL AND TISSUE RESEARCH, 309 (1). pp. 11-26. ISSN 0302-766X
Full text not available from this repository.Abstract
Mechanisms underlying circadian clock function in Drosophila melanogaster have been revealed by genetic and molecular approaches. Two interlocked transcriptional feedback loops involving at least the period, timeless, Clock, and cycle genes generate molecular oscillations that are believed to control behavioral rhythmicity and other clock outputs. These oscillations are further enhanced and fine-tuned to match the duration of the solar day by post-transcriptional and post-translational mechanisms depending on the PERIOD and TIMELESS proteins and on the protein kinases DOUBLETIME and SHAGGY. Light is the principal zeitgeber for synchronizing molecular and behavioral rhythmicity via the blue-light photoreceptor CRYPTOCHROME and the TIMELESS protein. In addition, light seems required for maintaining robust molecular oscillations at least in peripheral clock-gene-expressing tissues like the eyes, antennae, or Malpighian tubules. Relaying temporal information to cells and tissues expressing overt biological rhythms involves regulation of "output genes" at multiple levels. Although their regulation depends on the major clock genes, the majority of the clock-controlled genes are not direct targets of clock factors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GALACTOSIDASE FUSION PROTEIN; CIRCADIAN BEHAVIORAL RHYTHMS; PERIOD GENE-EXPRESSION; DOUBLE-TIME; MESSENGER-RNA; NERVOUS-SYSTEM; CREB PHOSPHORYLATION; MOLECULAR MECHANISMS; DISCONNECTED MUTANTS; BIOLOGICAL CLOCK; circadian rhythms; clock genes; cryptochrome; Drosophila; feedback loops |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 09 Jun 2021 07:12 |
| Last Modified: | 09 Jun 2021 07:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40104 |
Actions (login required)
 |
View Item |
