Pauly, Susanne and Broll, Karin and Wittmann, Margarethe and Giegerich, Gerhard and Schwarz, Herbert (2002) CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. JOURNAL OF LEUKOCYTE BIOLOGY, 72 (1). pp. 35-42. ISSN 0741-5400
Full text not available from this repository.Abstract
CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activation in monocytes. Here we show that B lymphocytes also receive costimulatory signals through the CD137 ligand. Immobilized CD137 augmented proliferation of preactivated B lymphocytes up to fivefold and immunoglobulin synthesis, up to threefold. C D 13 7 had no effect on resting cells. Further, we show that CD137 is expressed in vivo by follicular dendritic cells (FDC) in germinal centers. Germinal centers form during humoral immune responses and are essential for B lymphocyte affinity maturation. These data imply that, similar to the CD40 receptor/ligand system, which mediates T lymphocyte help to B lymphocytes after the first antigen encounter, the CD137 receptor/tigand system may mediate costimulation of B lymphocytes toy FDC during affinity maturation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR RECEPTOR FAMILY; MONOCYTE ACTIVATION; CD40 LIGAND; HUMAN 4-1BB; T-CELLS; PROLIFERATION; SURVIVAL; GROWTH; MEMBER; APOPTOSIS; antigen-presenting cells; hematoxylin/eosin; Staphylococcus aureus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Oct 2021 12:14 |
| Last Modified: | 18 Oct 2021 12:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40122 |
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