von Landenberg, Philipp and Schoelmerich, Juergen and Andreesen, Reinhard and Vogelhuber, Martin and Lackner, Karl J. (2002) A case of Waidenstroem's disease with a monoclonal IgM antiphospholipid antibody. RHEUMATOLOGY INTERNATIONAL, 22 (3). pp. 129-131. ISSN 0172-8172
Full text not available from this repository. (Request a copy)Abstract
The antiphospholipid syndrome (APS) was described in 1983 as a clinical entity characterized by venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. The serological markers of APS are antiphospholipid antibodies (APLA) directed mainly against anionic phospholipids, usually cardiolipin but also phosphatidylserine. Some APLA exhibit lupus anticoagulant activity. Monoclonal gammopathy sometimes occurs with the presence of autoantibodies. In this paper, we describe a patient with the diagnosis of immunocytoma with an IgM, kappa paraprotein with apparent specificity against anionic phospholipids, and lupus anticoagulant activity, but no clinical signs of APS. We describe in this patient the presence of a high titer of monoclonal APLA, which does apparently not induce the clinical symptoms of APS. This might be indicative for the presence of pathogenic and nonpathogenic antiphospholipid antibodies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTICARDIOLIPIN ANTIBODIES; ENDOTHELIAL-CELLS; BETA(2)-GLYCOPROTEIN-I; GAMMOPATHY; BINDING; M. Waldenstroem; antiphospholipid antibodies; cardiolipin; phosphatidylserine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2021 05:49 |
| Last Modified: | 19 Oct 2021 05:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40139 |
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