Thuerauf, Norbert and Guenther, Michaela and Pauli, Elizabeth and Kobal, Gerd (2002) Sensitivity of the negative mucosal potential to the trigeminal target stimulus CO2. BRAIN RESEARCH, 942 (1-2): PII S0006-. pp. 79-86. ISSN 0006-8993
Full text not available from this repository. (Request a copy)Abstract
CO2 is frequently used in an experimental pain model and in imaging studies investigating the central processing of trigeminal nociceptive information because of its specific trigeminal stimulation properties. The aim of the current study was (1) to investigate the sensitivity of the NMP to small increments of CO2 stimulus concentrations (3% CO2 v/v) and (2) to characterize the sensory input of CO, by determining NMP, detection and pain thresholds and by registering subjective verbal descriptions. Ten subjects participated in the first experimental sessions investigating NMP responses to stimuli of 62, 65, 68% CO2 (v/v) (stimulus duration: 1000 ms). Our statistical analysis revealed a dose-dependent increase of the NMP amplitudes and areas under the curves (AUCs) demonstrating the high dynamic resolution of the NMP. Ten subjects participated in the second experimental sessions determining thresholds for NMP, detection and pain (stimulus duration: 1000 ms). MANOVA analysis revealed significantly different thresholds for detection, NMP and subjective pain judgements (mean and S.D. as percentage CO2 (v/v): detection: 20.6 +/- 9.6, NMP: 42.6 +/- 12.5, pain: 50.4 +/- 12.0). We could demonstrate the existence of a prepain range below subjective pain thresholds with activation of trigeminal nociceptive sensors resulting in the generation of NMPs. The detection threshold of 20.6% CO2 (v/v) was surprisingly low, i.e. 22% CO2 (v/v) below the NMP threshold. The involvement of newly discovered alpha-gustducin positive trigeminal chemosensory cells in CO, detection is hypothesized, (C) 2002 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN NASAL-MUCOSA; REPETITIVE PAINFUL STIMULATION; MECHANICAL STIMULATION; RESPONSES; FIBERS; ODOR; NOCICEPTORS; IRRITATION; PUNGENCY; NICOTINE; NMP; trigeminal; pain; sensory detection; CO2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2021 06:10 |
| Last Modified: | 19 Oct 2021 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40144 |
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