Ruckert, Stefan and Hiendlmeyer, Elke and Brueckl, Wolfgang M. and Oswald, Ursula and Beyser, Kurt and Dietmaier, Wolfgang and Haynl, Angela and Koch, Claudia and Rueschoff, Josef and Brabletz, Thomas and Kirchner, Thomas and Jung, Andreas (2002) T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis. CANCER RESEARCH, 62 (11). pp. 3009-3013. ISSN 0008-5472
Full text not available from this repository. (Request a copy)Abstract
Colorectal carcinomas with microsatellite instability accumulate errors in short repetitive DNA repeats, especially mono and dinucleotide repeats. One such error-prone A(9) monorepeat is found in exon 17 of the TCF-4 gene. TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors. To elucidate the relevance of frameshift mutations in the TCF-4 in colorectal carcinogenesis, a variety of investigations in human tumors and cell lines was performed. It was found that mutations in the TCF-4 A(9) repeat do not contribute to tumorigenesis and seem to be passenger mutations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRIPTION FACTORS; BETA-CATENIN; CANCER; WNT; GENE; PATHWAY; TCF-4; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Oct 2021 10:48 |
| Last Modified: | 25 Oct 2021 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40176 |
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