Jordan, Wolfgang and Decker, Michael and Kamrowski, Heike and Brunner, Edgar and Ehrenreich, Hannelore and Hajak, Goeran (2002) Effects of cerebrovascular challenges on plasma endothelin. NEUROSCIENCE RESEARCH, 43 (2): PII S0168-. pp. 127-134. ISSN 0168-0102, 1872-8111
Full text not available from this repository. (Request a copy)Abstract
Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive-endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-I levels. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MIDDLE CEREBRAL-ARTERY; ACUTE ISCHEMIC STROKE; BLOOD-FLOW; SUBARACHNOID HEMORRHAGE; HYPERTENSIVE PATIENTS; TRANSCRANIAL DOPPLER; ARGININE-VASOPRESSIN; HEALTHY-SUBJECTS; MIGRAINE ATTACK; EXERCISE; CO2 inhalation; hypercapnia; hypocapnia; cerebral blood flow velocity; cerebral hemodynamics; immunoreactive endothelin-1 concentration; transcranial Doppler ultrasonography, TCD |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2021 05:47 |
| Last Modified: | 26 Oct 2021 05:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40215 |
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