Rodenbeck, Andrea and Huether, Gerald and Ruether, Eckart and Hajak, Goeran (2002) Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia. NEUROSCIENCE LETTERS, 324 (2): PII S0304-. pp. 159-163. ISSN 0304-3940
Full text not available from this repository. (Request a copy)Abstract
Recent research provides evidence for an interaction between sleep and the activation of the hypothalamic-pituitary-adrenal (HPA)-axis, but detailed studies in patients are still missing. We investigated hourly evening and nocturnal plasma cortisol secretion and sleep in seven male patients with severe chronic primary insomnia and age- and gender-matched controls. Evening and nocturnal cortisol levels were significantly increased in patients. Evening cortisol correlated with the number of nocturnal awakenings in patients and controls. Additionally, patients showed significant correlations between sleep parameters and the first 4 h of nocturnal cortisol secretion. These results are indicative of changes in the HPA system in insomnia and may reflect a path of physiological mechanism of chronic insomnia resulting in a vicious cycle of both disturbed HPA functions and chronic insomnia according to the arousal hypothesis of insomnia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING HORMONE; CIRCADIAN RHYTHMICITY; STRESS; EEG; ADRENOCORTICOTROPIN; CONSEQUENCES; cortisol; insomnia; sleep; hyperarousal; pathophysiology; hypothalamic-pituitary-adrenal-axis; interactions |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2021 08:17 |
| Last Modified: | 26 Oct 2021 08:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40249 |
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