Apers, Sandra and Paper, Dietrich and Buergermeister, Jutta and Baronikova, Slavka and Van Dyck, Stefaan and Lemiere, Guy and Vlietinck, Arnold and Pieters, Luc (2002) Antiangiogenic activity of synthetic dihydrobenzofuran lignans. JOURNAL OF NATURAL PRODUCTS, 65 (5). pp. 718-720. ISSN 0163-3864
Full text not available from this repository. (Request a copy)Abstract
A series of synthetic dihydrobenzofuran lignans, obtained by biomimetic oxidative dimerization of caffeic or ferulic acid methyl ester followed by derivatization reactions, was tested for its antiangiogenic activity in the CAM (chorioallantoic membrane) assay. The dimerization product of caffeic acid methyl ester (2a) (methyl (E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-3-methoxycarbonyl-2,3-dihydro-1-bunzofuran-5-yl]prop-2-enoate) showed a pronounced antiangiogenic activity, especially the 2R,3R-enantiomer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOGENESIS; INHIBITION; CANCER; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Oct 2021 07:01 |
| Last Modified: | 27 Oct 2021 07:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40345 |
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