Brunner, Henri and Schellerer, Karl-Martin (2002) Benzoporphyrins and acetylene-substituted porphyrins as improved photosensitizers in the photodynamic tumor therapy with porphyrin platinum conjugates. MONATSHEFTE FUR CHEMIE, 133 (5). pp. 679-705. ISSN 0026-9247, 1434-4475
Full text not available from this repository. (Request a copy)Abstract
A combination of a cisplatinum-like fragment and a porphyrin in the same molecule should not only result in the additivity of the dark toxicity of the platinum fragment and the phototoxicity of the porphyrin moiety, but also in the enrichment of the porphyrin platinum conjugates in tumor tissue, which cisplatinum alone does not show. To increase the penetration depth of the red light used in the photodynamic tumor therapy the conjugated system of the porphyrin components in porphyrin platinum conjugates had to be expanded. Sixteen new (NH3)(2)Pt derivatives of benzoporphyrins and acetylene-substituted porphyrins were synthesized. characterized, and tested with respect to their antitumor activity on the mammary carcinoma cell line MDA-MB-231.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIELS-ALDER REACTIONS; IN-VITRO; COUPLING REACTIONS; ANTITUMOR-ACTIVITY; PYRROLIC COMPOUNDS; PROTOPORPHYRIN-IX; COMPLEXES; HEMATOPORPHYRIN; LIGANDS; DERIVATIVES; photodynamic tumor therapy; porphyrin platinum conjugates; benzoporphyrins; acetylene-substituted porphyrins; MDA-MB-231 cell line |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Henri Brunner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Oct 2021 08:41 |
| Last Modified: | 27 Oct 2021 08:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40351 |
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