Bucher, Michael and Hobbhahn, Jonny and Taeger, Kai and Kurtz, Armin (2002) Cytokine-mediated downregulation of vasopressin V-1A receptors during acute endotoxemia in rats. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 282 (4). R979-R984. ISSN 0363-6119, 1522-1490
Full text not available from this repository. (Request a copy)Abstract
The reduced pressure response to vasopressin during acute sepsis has directed our interest to the regulation of vasopressin V-1A receptors. Rats were injected with lipopolysaccharide for induction of experimental gram-negative sepsis. V-1A receptor gene expression was downregulated in the liver, lung, kidney, and heart during endotoxemia. Inasmuch as the concentrations of proinflammatory cytokines such as interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma were highly increased during sepsis, the influence of these cytokines on V-1A receptor expression was investigated in primary cultures of hepatocytes and in the aortic vascular smooth muscle cell line A7r5. V-1A receptor expression was downregulated by the cytokines in a nitric oxide-independent manner. Blood pressure dose-response studies after injection of endotoxin showed a diminished responsiveness to the selective V-1 receptor agonist Phe(2),Ile(3),Orn(8)-vasopressin. Our data show that sepsis causes a downregulation of V-1A receptors and suggest that this effect is likely mediated by proinflammatory cytokines. We propose that this downregulation of V-1A receptors contributes to the attenuated responsiveness of blood pressure in response to vasopressin and, therefore, contributes to the circulatory failure in septic shock.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE CELLS; II TYPE-2 RECEPTOR; ANGIOTENSIN-II; SEPTIC SHOCK; ARGININE-VASOPRESSIN; GENE-EXPRESSION; CONSCIOUS RATS; TNF-ALPHA; blood pressure; hepatocytes; vascular smooth muscle; A7r5 cell line; nitric oxide |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2021 09:34 |
| Last Modified: | 02 Nov 2021 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40391 |
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