Kunz-Schughart, Leoni A. and Knuechel, Ruth (2002) Tumor-associated fibroblasts (Part I): active stromal participants in tumor development and progression? HISTOLOGY AND HISTOPATHOLOGY, 17 (2). pp. 599-621. ISSN 0213-3911, 1699-5848
Full text not available from this repository. (Request a copy)Abstract
Phenotypic and functional characteristics of tumor associated fibroblasts (TAF) in contrast to normal fibroblasts are reviewed in this first synopsis (part 1). Terms as tumor stroma, desmo-plasia, TAF, myofibroblast, and fetal-type fibroblast are defined, and experimental systems to study heterologous cell interactions are presented. While we only start to gather information on the genotype of TAF, a broad range of data deals with the expression profile of these cells, covering e.g. ECM and ECM-modulating molecules, growth factors and cytokines. Summarizing the recent state of knowledge indicates that TAF provide sources for tumor diagnosis and therapy, that have to be further defined in an organ-specific approach in terms of the functional impact on the tumor cell and its environment (see part II).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; HUMAN BREAST-CANCER; GROWTH-FACTOR-BETA; HUMAN LUNG FIBROBLASTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MATRIX METALLOPROTEINASE INDUCER; HUMAN DERMAL FIBROBLASTS; SMOOTH MUSCLE ACTIN; INTERCELLULAR-ADHESION MOLECULE-1; INVASIVE DUCTAL CARCINOMA; desmoplasia; fibroblast; myofibroblast; oncofetal extracellular matrix; matrix metalloproteinases; integrins; cell adhesion molecules; growth factors; cytokines; chemokines; multicellular spheroid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 08 Jun 2021 09:36 |
| Last Modified: | 08 Jun 2021 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40417 |
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