Stephan, Michael and Straub, Rainer H. and Breivik, Torbjorn and Pabst, Reinhard and von Hoersten, Stephan (2002) Postnatal maternal deprivation aggravates experimental autoimmune encephalomyelitis in adult Lewis rats: reversal by chronic imipramine treatment. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 20 (2): PII S0736-. pp. 125-132. ISSN 0736-5748, 1873-474X
Full text not available from this repository. (Request a copy)Abstract
Stressful experiences can modulate multiple sclerosis, but stress protection is currently not considered a treatment option. Here, we show that maternal deprivation, an adverse stress experience in infancy, increases emotionality in behavioral tests of adult female Lewis rats and concomitantly causes a more severe course of experimental autoimmune encephalomyelitis. Treatment of these effects in adulthood by chronic antidepressants (imipramine) reversed the behavioral symptoms and attenuated the Course of the encephalomyelitis in deprived rats. Increased IL-4 plasma levels accompanied the protective-like effects of antidepressants. In contrast, attempts to prevent these effects in infancy by tactile stimulation aggravated the encephalomyelitis, possibly by decreasing corticosterone and increasing IFN-gamma levels during the disease. This indicates that antidepressants exert protective effects in an animal model of multiple sclerosis, and suggests that drugs modifying stress responsiveness may have a potential role as adjuvant treatment of the disease. (C) 2002 ISDN. Published by Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; DA RATS; PSYCHOLOGICAL STRESS; ADVERSE EXPERIENCES; IMMUNE-RESPONSE; BRAIN STRUCTURE; stress; exploratory behavior; cytokines; physical stimulation; development |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2021 13:53 |
| Last Modified: | 02 Nov 2021 13:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40421 |
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