Schlachetzki, Felix and Zhu, Chunni and Pardridge, William M. (2002) Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. JOURNAL OF NEUROCHEMISTRY, 81 (1). pp. 203-206. ISSN 0022-3042
Full text not available from this repository.Abstract
The blood-brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction, However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR, The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co-localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the 'reverse transcytosis' of IgG in the brain to blood direction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | I-RELATED RECEPTOR; IMMUNOGLOBULIN-G; GLUCOSE TRANSPORTER; IGG; ANTIBODIES; PROTECTION; CATABOLISM; SYSTEM; GLUT-1; KIDNEY; biological transport; blood-brain barrier; endothelium; neonatal Fc receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Nov 2021 06:28 |
| Last Modified: | 03 Nov 2021 06:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40434 |
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