Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes

Niller, Hans Helmut and Salamon, Daniel and Uhlig, Joerg and Ranf, Stefanie and Granz, Marcus and Schwarzmann, Fritz and Wolf, Hans and Minarovits, Janos (2002) Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes. JOURNAL OF VIROLOGY, 76 (8). pp. 4113-4118. ISSN 0022-538X

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Abstract

Genomic footprints across Rp, Zp, and oriLyt of Epstein-Barr virus (EBV) have been conducted in a panel of latently infected B-cell lines. Close protein-base contacts were found about 360 nucleotides upstream of the Zp initiation site. Gel shifts and transient transfection assays indicated that an Sp1-NF1 locus may serve as a repressive transcriptional element against Zp induction from latent EBV genomes.

Item Type: Article
Uncontrolled Keywords: EARLY BRLF1 PROMOTER; CIS-ACTING ELEMENTS; LYTIC CYCLE GENES; DNA-REPLICATION; TRANSCRIPTION FACTOR; BZLF1 GENE; PRODUCTIVE CYCLE; DIVERGENT PROMOTER; RTA PROTEIN; EBV GENOME;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Depositing User: Dr. Gernot Deinzer
Date Deposited: 03 Nov 2021 07:59
Last Modified: 03 Nov 2021 07:59
URI: https://pred.uni-regensburg.de/id/eprint/40441

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