Roessler, Wolfgang and Filbeck, T. and Wieland, W. F. (2002) Transurethral resection of bladder tumours induced by fluorescence diagnosis using 5 aminolevulinic acid. AKTUELLE UROLOGIE, 33 (2). pp. 136-140. ISSN 0001-7868
Full text not available from this repository. (Request a copy)Abstract
Purpose: Transurethral resection (TUR) of bladder cancer supported by 5 aminolevulinic acid (ALA) induced fluorescence diagnosis (FD) is considered to be a very sensitive procedure. In this unicentric prospective trial, the sensitivity of FD was compared to conventional white light TUR. Materials and Methods: A total of 787 biopsies or tumors could be obtained from 310 patients. For fluorescence 50 ml of 5-ALA 3% solution was instilled intravesically 2 hours prior to resection. Excitation was achieved using a special diagnostic light emitting blue light with wave lengths of 375 - 440 nm. Results: The sensitivity of FD (97.6%) was significantly higher (p<0.0001) than white light cystoscopy (77.2%). In 43 patients, 62 carcinomas and dysplasias overlooked by white light could be detected exclusively by FD (n = 26 pTa/1G1 - 2, n - 2 pT1G2, n = 3 pT1G3, n - 16 CIS, n = 2 > pT1 and n = 13 dysplasia H). Additional carcinomas in situ (CIS) were detected in 53.3% of the cases using FD. Conclusions: These data confirm that FD is a procedure with a very high sensitivity and clearly improves detection of tumours overlooked under conventional white light, especially CIS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL-CARCINOMA; 5-AMINOLEVULINIC ACID; INTRAVESICAL INSTILLATION; TUMORS; bladder cancer; aminolevulinic acid; fluorescence; diagnosis; cystoscopy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2021 08:00 |
| Last Modified: | 08 Nov 2021 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40477 |
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