Krause, Stefan W. and Gnad, Marcus and Reichle, Albrecht and Andreesen, Reinhard (2002) Adoptive therapy with monocyte-derived macrophages in the setting of high-dose chemotherapy and peripheral blood stem cell transplantation. BRITISH JOURNAL OF HAEMATOLOGY, 116 (4). pp. 920-922. ISSN 0007-1048
Full text not available from this repository. (Request a copy)Abstract
In an attempt to ameliorate chemotherapy-induced side-effects after transplantation of autologous peripheral blood stem cells (PBSCT), we tested the reinfusion of autologous macrophages (MAC) that are known to be potent antimicrobial effector cells and cytokine producers. Ten patients were treated with two sequential cycles of high-dose chemotherapy followed by PBSCT. Before the second cycle of PBSCT. mononuclear cells were harvested. cultured for 8 d in order to induce MAC maturation and reinfused 3 d after PBSCT without clinical problems. However, MAC infusions did not substantially alleviate the toxicity of autologous PBSCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNOTHERAPY; peripheral blood stem cell transplantation; chemotherapy; complications; immunotherapy; macrophages |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2021 10:19 |
| Last Modified: | 08 Nov 2021 10:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40489 |
Actions (login required)
 |
View Item |
