Dzau, Victor J. and Bernstein, Kenneth and Celermajer, David and Cohen, Jerome and Dahloef, Bjoern and Deanfield, John and Diez, Javier and Drexler, Helmut and Ferrari, Roberto and van Gilst, Wiek and Hansson, Lennart and Hornig, Burkhard and Husain, Ahasan and Johnston, Colin and Lazar, Harold and Lonn, Eva and Luescher, Thomas and Mancini, John and Mimran, Albert and Pepine, Carl and Rabelink, Ton and Remme, Willem and Ruilope, Luis and Ruzicka, Marcel and Schunkert, Heribert and Swedberg, Karl and Unger, Thomas and Vaughan, Douglas and Weber, Michael (2002) Pathophysiologic and therapeutic importance of tissue ACE: A consensus report. CARDIOVASCULAR DRUGS AND THERAPY, 16 (2). pp. 149-160. ISSN 0920-3206, 1573-7241
Full text not available from this repository. (Request a copy)Abstract
Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular function and structure; thus, the predominant localization of ACE to the endothelium has implications for the pathobiology of vascular disease, such as coronary artery disease. Numerous experimental studies and clinical trials support the emerging realization that tissue ACE is a vital therapeutic target, and that its inhibition may restore endothelial function or prevent endothelial dysfunction. These effects exceed those attributable to blood pressure reduction alone; hence, ACE inhibitors may exert an important part of their effects through direct tissue action. Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOTENSIN-CONVERTING-ENZYME; PRESSURE-OVERLOAD HYPERTROPHY; LEFT-VENTRICULAR HYPERTROPHY; INDUCED CARDIAC-HYPERTROPHY; EXPERIMENTAL HEART-FAILURE; MYOCARDIAL-INFARCTION; ENDOTHELIAL DYSFUNCTION; AORTIC-STENOSIS; ANTIHYPERTENSIVE THERAPY; GENE-EXPRESSION; tissue ACE; angiotensin-converting enzyme inhibitors; endothelial dysfunction; cardiovascular disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2021 10:32 |
| Last Modified: | 08 Nov 2021 10:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40492 |
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