Zimmermann, J. and Kuehl, A. A. and Weber, M. and Gruen, J. R. and Loeffler, J. and Haftmann, C. and Riedel, R. and Maschmeyer, P. and Lehmann, K. and Westendorf, K. and Mashreghi, M-F and Loehning, M. and Mack, M. and Radbruch, A. and Chang, H. D. (2016) T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis. MUCOSAL IMMUNOLOGY, 9 (6). pp. 1487-1499. ISSN 1933-0219, 1935-3456
Full text not available from this repository. (Request a copy)Abstract
The transcription factor T-bet is highly expressed by Th cells isolated from the inflamed intestine of Crohn's disease patients, and has been regarded a critical driver of murine T cell-induced colitis. However, we show here that T-bet expression by Th cells is not required for the manifestation of T-cell-induced colitis in the presence of segmented filamentous bacteria and Helicobacter hepaticus. T-bet expression by Th cells controls their survival and localization, their repertoire of chemokine and chemokine receptor expression, the accumulation of monocytes and macrophages in the inflamed colon, and their differentiation to the M1 type, i.e., type 1 inflammation. Nevertheless, T-bet-deficient Th cells efficiently induce colitis, as reflected by weight loss, diarrhea, and colon histopathology. T-bet-deficient Th cells differentiate into Th1/17 cells, able to express IFN-gamma and IL-17A upon restimulation. While neutralization of IL-17A exacerbated colitis induced by wild-type or T-bet-deficient Th cells, neutralization of IFN-gamma completely abolished colitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC INTESTINAL INFLAMMATION; ROR-GAMMA-T; INNATE LYMPHOID-CELLS; BOWEL-DISEASE; IFN-GAMMA; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; CROHNS-DISEASE; SCID MICE; ALLOGRAFT-REJECTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2019 07:54 |
| Last Modified: | 24 Apr 2019 07:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4052 |
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