Eichhammer, Peter and Kharraz, A. and Wiegand, R. and Langguth, B. and Frick, U. and Aigner, J. M. and Hajak, G. (2002) Sleep deprivation in depression - Stabilizing antidepressant effects by repetitive transcranial magnetic stimulation. LIFE SCIENCES, 70 (15): PII S0024-. pp. 1741-1749. ISSN 0024-3205, 1879-0631
Full text not available from this repository. (Request a copy)Abstract
Partial sleep deprivation (PSD) has a profound and rapid effect on depressed mood. However, the transient antidepressant effect of PSD - most patients relapse after one night of recovery sleep-is limiting the clinical use of this method. Using a controlled, balanced parallel design we studied, whether repetitive transcranial magnetic stimulation (rTMS) applied in the morning after PSD is able to prevent this relapse. 20 PSD responders were randomly assigned to receive either active or sham stimulation during the following 4 days after PSD. Active stimulation prolonged significantly (p < 0.001) the antidepressant effect of PSD up to 4 days. This finding indicates that rTMS is an efficacious method to prevent relapse after PSD. (C) 2002 Elsevier Science Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PREFRONTAL CORTEX; ELECTROCONVULSIVE-THERAPY; TREATMENT RESPONSE; RAT-BRAIN; METABOLISM; PERFUSION; CINGULATE; RELAPSE; RELEASE; NUCLEUS; depression; sleep deprivation; relapse; repetitive transcranial magnetic stimulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Nov 2021 16:09 |
| Last Modified: | 08 Nov 2021 16:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40538 |
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