Pallares, Fernando Perez de los Cobos and Bautista, Tara G. and Stanic, Davor and Egger, Veronica and Dutschmann, Mathias (2016) Brainstem-mediated sniffing and respiratory modulation during odor stimulation. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 233. pp. 17-24. ISSN 1569-9048, 1878-1519
Full text not available from this repository. (Request a copy)Abstract
The trigeminal and olfactory systems interact during sensory processing of odor. Here, we investigate odor-evoked modulations of brainstem respiratory networks in a decerebrated perfused brainstem preparation of rat with intact olfactory bulbs. Intranasal application of non-trigeminal odors (rose) did not evoke respiratory modulation in absence of cortico-limbic circuits. Conversely, trigeminal odors such as menthol or lavender evoked robust respiratory modulations via direct activation of preserved brain stem circuits. Trigeminal odors consistently triggered short phrenic nerve bursts (fictive sniff), and the strong trigeminal odor menthol also triggered a slowing of phrenic nerve frequency. Phrenic and vagal nerve recordings reveal that fictive sniffs transiently interrupted odor evoked tonic postinspiratory vagal discharge. This motor pattern is significantly different from normal (eupneic) respiratory activity. In conclusion, we show for the first time the direct involvement of brainstem circuits in primary odor processing to evoke protective sniffs and respiratory modulation in the complete absence of forebrain commands. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTERIOR ETHMOIDAL NERVE; KOLLIKER-FUSE NUCLEI; NASAL-MUCOSA; HORSERADISH-PEROXIDASE; ELECTRICAL-STIMULATION; CENTRAL PROJECTIONS; DIVING RESPONSE; C-FOS; RAT; REFLEX; Trigeminal; Brainstem; Behavior |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurophysiologie (Prof. Dr. Veronica Egger) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2019 07:48 |
| Last Modified: | 24 Apr 2019 07:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4062 |
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