Broeckel, Ulrich and Hengstenberg, Christian and Mayer, Bjoern and Holmer, Stephan and Martin, Lisa J. and Comuzzie, Anthony G. and Blangero, John and Nuernberg, Peter and Reis, Andre and Riegger, Guenter A. J. and Jacob, Howard J. and Schunkert, Heribert (2002) A comprehensive linkage analysis for myocardial infarction and its related risk factors. NATURE GENETICS, 30 (2). pp. 210-214. ISSN 1061-4036
Full text not available from this repository. (Request a copy)Abstract
Coronary artery disease and myocardial infarction (MI) are leading causes of death in the western world. Numerous studies have shown that risk factors such as diabetes mellitus, arterial hypertension and hypercholesterolemia contribute to the development of the disease. Although each risk factor by itself is partly under genetic control, a positive family history is an independent predictor, which suggests that there are additional susceptibility genes(1). We have scanned the whole genome in 513 families to identify chromosomal regions linked to myocardial infarction and related risk factors that are known to be under genetic control. Here we show, by using variance component analysis and incorporating risk factors, that risk of myocardial infarction maps to a single region on chromosome 14 with a significant lod score of 3.9 (pointwise P=0.00015, genome-wide P<0.05), providing evidence of a principal MI locus. To characterize this locus we analyzed each risk factor by itself. Serum concentrations of lipoprotein (a) show linkage to both the apolipoprotein (a) locus (lod score 26.99) and a new locus on chromosome 1 (lod score 3.8). There is suggestive linkage for diabetes mellitus on chromosome 6 (lod score 2.96), for hypertension on chromosomes 1 and 6, for high-density and low-density lipoprotein cholesterol on chromosomes 1 and 17, and for triglyceride concentrations on chromosome 9. Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY HEART-DISEASE; SUSCEPTIBILITY LOCUS; DIABETES-MELLITUS; GENETIC-LINKAGE; UNITED-STATES; PAIR ANALYSIS; CHROMOSOME; HYPERTENSION; PEDIGREES; DESCENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 07:25 |
| Last Modified: | 15 Nov 2021 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40646 |
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