Guba, Markus and von Breitenbuch, Philipp and Steinbauer, Markus and Koehl, Gudrun and Flegel, Stefanie and Hornung, Matthias and Bruns, Christiane J. and Zuelke, Carl and Farkas, Stefan and Anthuber, Matthias and Jauch, Karl-Walter and Geissler, Edward K. (2002) Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. NATURE MEDICINE, 8 (2). pp. 128-135. ISSN 1078-8956
Full text not available from this repository. (Request a copy)Abstract
Conventional immunosuppressive drugs have been used effectively to prevent immunologic rejection in organ transplantation. Individuals taking these drugs are at risk, however, for the development and recurrence of cancer. In the present study we show that the new immunosuppressive drug rapamycin (RAPA) may reduce the risk of cancer development while simultaneously providing effective immunosuppression. Experimentally, RAPA inhibited metastatic tumor growth and angiogenesis in in vivo mouse models. In addition, normal immunosuppressive doses of RAPA effectively controlled the growth of established tumors. In contrast, the most widely recognized immunosuppressive drug, cyclosporine, promoted tumor growth. From a mechanistic perspective, RAPA showed antiangiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF) and to a markedly inhibited response of vascular endothelial cells to stimulation by VEGF. Thus, the use of RAPA, instead of cyclosporine, may reduce the chance of recurrent or de novo cancer in high-risk transplant patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SIGNAL-TRANSDUCTION; LIVER METASTASES; CYCLOSPORINE-A; IN-VITRO; ANGIOGENESIS; MECHANISM; CANCER; CELLS; PROGRESSION; CARCINOMA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 07:29 |
| Last Modified: | 15 Nov 2021 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40647 |
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