Suh, Greg S. B. and Poeck, Burkhard and Chouard, Tanguy and Oron, Efrat and Segal, Daniel and Chamovitz, Daniel A. and Zipursky, S. Lawrence (2002) Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. NEURON, 33 (1). pp. 35-46. ISSN 0896-6273
Full text not available from this repository. (Request a copy)Abstract
Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia, The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLARITY GENE HEDGEHOG; COP9 SIGNALOSOME; AXON GUIDANCE; BITHORAX COMPLEX; NERVOUS-SYSTEM; VISUAL-SYSTEM; MELANOGASTER; PROTEIN; LIGHT; ARABIDOPSIS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 10:25 |
| Last Modified: | 15 Nov 2021 10:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40675 |
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