Wiesner, G. and Schrogendorfer, K. and Horauf, Klaus and Sobczynski, Pavel and Harth, Maximilian and Taeger, K. and Rudiger, H. W. (2002) A high occupational exposure to inhaled anaesthetics is associated with an increased formation of sister chromatid exchanges - A study on the genotoxicity of inhaled anaesthetics. ANASTHESIOLOGIE & INTENSIVMEDIZIN, 43 (1). pp. 16-20. ISSN 0170-5334
Full text not available from this repository.Abstract
The sister chromatid exchange-assay is a standard procedure to assess an exposure to genotoxic agents. Recently, a study was published on sister chromatid exchanges in operating room personnel exposed to low concentrations of waste anaesthetic gases. It was demonstrated that the fraction of sister chromatid exchanges (SCE) was increased by 1 SCE / cell versus the matched control group. In the present study we demonstrate that the increase was 2.8 SCE / cell in anaesthesists and anaesthetic nurses of an East European university hospital (exposed to 170 ppm N2O and 4 ppm halothane and isoflurane). We conclude that there is a dose-response relationship between exposure levels and the formation of sister chromatid exchanges.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPERATING-ROOM PERSONNEL; CHROMOSOME-ABERRATIONS; ANESTHETIC-GASES; NITROUS-OXIDE; DENTAL ASSISTANTS; LYMPHOCYTES; CANCER; MICRONUCLEI; sister chromatid exchange; occupational exposure; personnel; hospital; anaesthetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 10:54 |
| Last Modified: | 15 Nov 2021 10:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40684 |
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