Pap, Thomas and Gay, Renate E. and Mueller-Ladner, Ulf and Gay, Steffen (2002) Ex vivo gene transfer in the years to come. ARTHRITIS RESEARCH & THERAPY, 4 (1). ISSN 1478-6354, 1478-6362
Full text not available from this repository. (Request a copy)Abstract
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation rate and heterogeneity of RA-SFs, together with their lack of highly specific surface receptors, have hampered a more extensive application of this technique. Improving transduction protocols with conventional viral vectors, therefore, as well as developing novel strategies, such as alternative target cells, and novel delivery systems constitute a major challenge. Recent progress in this field will lead to the achievement of high transgene expression, and will facilitate the use of gene transfer in human trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; ex vivo approach; gene therapy; rheumatoid arthritis; viral vector |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 14:13 |
| Last Modified: | 15 Nov 2021 14:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40701 |
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