Droste, Dirk Wolfgang and Llull, Jean Bernard and Pezzoli, Carla and Bogdahn, Ulrich and Kaps, Manfred (2002) SonoVue (R) (BR1), a new long-acting echocontrast agent, improves transcranial colour-coded duplex ultrasonic imaging. CEREBROVASCULAR DISEASES, 14 (1). pp. 27-32. ISSN 1015-9770
Full text not available from this repository. (Request a copy)Abstract
Background and Purpose: Visualization of normal or pathological flow in the intracranial arteries using transcranial colour-coded duplex sonography (TCCS) is occasionally obstructed by insufficient temporal bone windows, unfavourable insonation angles, or low flow velocities or volumes. SonoVue(R) (BR1) is a new, long-acting echocontrast agent, which could be helpful in these instances. Methods: SonoVue was studied in two separate multicentre investigations of patients with insufficient bone windows (BR1-014 with 73 patients and 13131017 with 40 patients) using an identical protocol. The agent was given intravenously as a bolus in four different doses (0.3, 0.6, 1.2 and 2.4 ml). Evaluation was performed on-site and off-site with video clips. Results: The contrast agent was well tolerated. As compared to the precontrast scans, SonoVue facilitated the visualization of vessel patency, stenosis, occlusion, and collateral flow, decreased the need for additional tests, and had an impact on the patient's treatment. In 66-74%, a non-diagnostic investigation was converted into a diagnostic investigation. The highest dose (2.4 ml) allowed for a clinically useful signal enhancement of a median 1.9-6.3 min. Conclusions: SonoVue at a single dose of 1.2 or 2.4 ml is effective in increasing the detection of normal or pathological flow in the intracerebral arteries in patients who do not have a fully diagnostic unenhanced TCCS examination. Copyright (C) 2002 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CAROTID-ARTERY OCCLUSION; CEREBROVASCULAR-DISEASE; VERTEBROBASILAR SYSTEM; COLLATERAL PATHWAYS; ACUTE STROKE; SONOGRAPHY; ENDARTERECTOMY; BENEFIT; FLOW; ultrasonography; duplex scanning; contrast media; SonoVue (R) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Nov 2021 14:30 |
| Last Modified: | 15 Nov 2021 14:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40711 |
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