Bucher, M. and Mair, G. and Kees, Frieder (2002) Effect of roxithromycin on the pharmacokinetics of lovastatin in volunteers. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 57 (11). pp. 787-791. ISSN 0031-6970
Full text not available from this repository. (Request a copy)Abstract
Objective: To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinctics of lovastatin. Methods: In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment with roxithromycin 30 mg daily. Plasma concentrations of lovastatin (lactone and acid) were determined using high-performance liquid chromatography, and the pharmacokinetic parameters were estimated. Results: The mean (+/-SD) pharmacokinetic parameters of lovastatin lactone with and without roxithromycin were maximum concentration (C-max) 8.49 +/- 6.80/16.3 +/- 9.4ng ml(-1), time to Cmax (t(max)) 1.8 +/- 04/1.7 +/- 0.6h, terminal plasma half-life (t(1/2)) 4.3 +/- 2.0/3.7 +/- 2.5 h, area under the plasma concentration-time curve from zero to infinity (AUC(0) (infinity)) 53 +/- 60/85 +/- 67 ng ml(-1) h. The respective parameters of lovastatin acid were C-max 24.6 +/- 13.4/17.8 +/- 11.0 ng ml(-1), t(max) 3.7 +/- 1.1/4.1 +/- 0.7 h, t(1/2) 3.2 +/- 2.5/4.3 +/- 2.8 h, AUC(0) (infinity) 149 +/- 123/105 +/- 58 ng ml(-1) h. Mean bioavailability of lovastatin lactone was lower and that of lovastatin acid was higher with concomitant treatment. However, the differences were significant only with respect to lovastatin lactone (AUC and C-max) and C-max of lovastatin acid. Conclusion: Roxithromycin does not influence the pharmacokinetics of lovastatin in such a way that dosage adjustment of lovastatin seems to be necessary during co-administration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFORMANCE LIQUID-CHROMATOGRAPHY; REDUCTASE INHIBITORS; GRAPEFRUIT JUICE; ERYTHROMYCIN; SIMVASTATIN; THERAPY; ACID; ATHEROSCLEROSIS; RHABDOMYOLYSIS; ANTIBACTERIALS; lovastatin; roxithromycin; pharmacokinetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Frieder Kees |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Nov 2021 05:48 |
| Last Modified: | 16 Nov 2021 05:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40734 |
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