Koch, Horst J. and Raschka, C. (2002) Anthropometric data and acetylsalicylic acid pharmacokinetics. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 40 (1). pp. 30-34. ISSN 0946-1965
Full text not available from this repository. (Request a copy)Abstract
The relationship between anthropometric data and pharmacokinetic characteristics of acetylsalicylic acid (ASA) after administration of a single oral dose of 500 mg ASA, an oral and intravenous dose of 500 mg D,L-lysine-mono-acetyl sa I icy late (Lys-ASA) and an oral dose of 1.000 mg Lys-ASA were evaluated. Individual data from an open, randomized crossover trial ill 13 healthy volunteers (age 18 - 50 years, 6 female, 7 male, height 158 - 189 cm, weight 45 - 118 kg) were re-analyzed using a non-compartmental approach. The influence of body weight, height, body surface area and age on pharmacokinetic characteristics (C-max, T-max, AUC(last), MRTlast, t(1/2), Cl, Vd) was assessed using the multiple regression method and pairwise multiple correlations were calculated. Multiple regression analysis showed significant multiple correlation coefficients of approximately 0.86 for C-max (500 mg Lys-ASA i.v., 1,000 mg Lys-ASA per os and 500 mg ASA per os), Cl and AUC(last) (1,000 1119 Lys-ASA per os). Standardized regression values (P) reflected a major contribution for height, weight and body surface area, but age was not a relevant factor. Pair-wise comparisons confirmed negative correlations between anthropometric characteristics and C-max, AUC(last), and MRTlast and positive correlations between anthropometric data, Cl and Vd. In conclusion, apart from T-max and t(1/2), all pharmacokinetic characteristics were influenced by body weight, height and body surface area. Whereas repeated administration of high doses in patients with low body weights may give rise to toxic effects, acute single dose administration would not lead to significant under-dosing in tall or stout patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE; METABOLITES; ASPIRIN; DOSAGE; AGE; pharmacokinetic characteristics; anthropometric parameters; pharmacokinetic scaling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Nov 2021 08:08 |
| Last Modified: | 16 Nov 2021 08:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40763 |
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