Echtenacher, Bernd and Maennel, Daniela N. (2002) Requirement of TNF and TNF receptor type 2 for LPS-induced protection from lethal septic peritonitis. JOURNAL OF ENDOTOXIN RESEARCH, 8 (5). pp. 365-369. ISSN 0968-0519
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Pretreatment of mice with low quantities of LPS induces endotoxin tolerance characterized by enhanced resistance to lethal doses of LPS and to a number of infectious challenges. Mice subjected to cecal ligation and puncture (CLP) survived the ensuing septic peritonitis significantly better when they had been pretreated with LPS. This LPS-induced protection was dependent on endogenous TNF production capacity since LPS pretreatment did not protect TNF-deficient mice from death after CLP. While mice deficient in the TNF receptor type 2 (p75TNFR) were as sensitive to CLP-induced mortality as control mice, LPS pretreatment could not reduce mortality in p75TNFR-deficient mice after CLP. Therefore, activation of the TNF receptor type 2 by endogenous TNF constitutes an important interaction for the development of LPS-induced resistance to bacterial infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; MICE; ENDOTOXIN; PROLIFERATION; INFECTION; DEFICIENT; IMMUNE; CELLS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Nov 2021 10:56 |
| Last Modified: | 16 Nov 2021 10:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40768 |
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