Ackermann, G. and Hartmann, M. and Scherer, K. and Lang, Elmar W. and Hohenleutner, U. and Landthaler, M. and Baeumler, Wolfgang (2002) Correlations between light penetration into skin and the therapeutic outcome following laser therapy of port-wine stains. LASERS IN MEDICAL SCIENCE, 17 (2). pp. 70-78. ISSN 0268-8921
Full text not available from this repository. (Request a copy)Abstract
For several years the flashlamp-pumped pulsed dye laser (FPDL) has been the favoured method for the treatment of port-wine stains (PWS). The therapeutic outcome of FPDL laser therapy depends on the anatomical location of the PWS and is mainly attributed to morphological parameters such as size and depth of the PWS blood vessels. The aim of this study was to show a correlation between the therapeutic outcome following FPDL therapy and the optical properties of the skin overlying the PWS vessels. For this purpose the therapeutic outcome following FPDL treatment (585 nm; 0.45 ms) of 884 PWS situated on different body sites was evaluated by judging the grade of fading of PWS colour. On the other hand the light penetration into 123 skin samples (thickness 0.10-1.35 mm) was determined between 450 nm and 1030 nm and compared with the PWS laser therapy outcome for equal locations by statistical analysis. PWS on the neck, trunk, arms or legs yielded a higher mean grade of fading as compared to PWS on the head. Within the face, a wide range of fading was evident. The light penetration into skin increased linearly with increasing wavelength and location-dependent differences were found. The attenuation coefficient was 22.8 +/- 5.3 mm(-1) at 585 nm. No significant or strong correlation was observed between the therapeutic outcome of PWS laser therapy and the light penetration into skin. However, a correlation was obvious by plotting the respective profile plots. Therefore, among other effects, in particular morphological parameters of PWS vessels, the optical properties of the skin contribute to a small extent to the clinical outcome of PWS laser therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULSED DYE-LASER; CHILDREN; COMPLICATIONS; OPTICS; flashlamp-pumped pulsed dye laser; light penetration; optical properties; port-wine stains; skin |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Elmar Lang |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Nov 2021 15:13 |
| Last Modified: | 17 Nov 2021 15:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40782 |
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