Kraft, Clayton N. and Burian, Björn and Perlick, Lars and Wimmer, Markus A. and Wallny, Thomas and Schmitt, Ottmar and Diedrich, Oliver (2001) Impact of a nickel-reduced stainless steel implant on striated muscle microcirculation: A comparative in vivo study. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 57 (3). pp. 404-412. ISSN 0021-9304
Full text not available from this repository.Abstract
The impairment of skeletal muscle microcirculation by a biomaterial may have profound consequences. With moderately good physical and corrosion characteristics, implant-quality stainless steel is particularly popular in orthopedic surgery. However, due to the presence of a considerable amount of nickel in the alloy, concern has been voiced in respect to local tissue responses. More recently a stainless steel alloy with a significant reduction of nickel has become commercially available. We, therefore, studied bi vivo nutritive perfusion and leukocytic response of striated muscle to this nickel-reduced alloy, and compared these results with those of the materials conventional stainless steel and titanium. Using the hamster dorsal skinfold chamber preparation and intravital microscopy, we could demonstrate that reduction of the nickel quantity in a stainless steel implant has a positive effect on local microvascular parameters. Although the implantation of a conventional stainless steel sample led to a distinct and persistent activation of leukocytes combined with disruption of the microvascular endothelial integrity, marked leukocyte extravasation, and considerable venular dilation, animals with a nickel-reduced stainless steel implant showed only a moderate increase of these parameters, with a clear tendency of recuperation. Titanium implants merely caused a transient increase of leukocyte-endothelial cell interaction within the first 120 min, and no significant change in macromolecular leakage, leukocyte extravasation, or venular diameter. Pending biomechanical and corrosion testing, nickel-reduced stainless steel may be a viable alternative to conventional implant-quality stainless steel for biomedical applications. Concerning tolerance by the local vascular system, titanium currently remains unsurpassed, (C) 2001 John Wiley & Sons, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MICROVASCULAR RESPONSE; ORTHOPEDIC IMPLANTS; METAL-IONS; TOXICITY; TISSUE; MICROSCOPY; LEUKOCYTES; PRODUCTS; TITANIUM; ADHESION; nickel; stainless steel; osteosynthesis materials; microcirculation; biocompatibility |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Nov 2021 09:33 |
| Last Modified: | 23 Nov 2021 09:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40879 |
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