Iwasa, Kinuko and Moriyasu, Masataka and Tachibana, Yoko and Kim, Hye-Sook and Wataya, Yusuke and Wiegrebe, Wolfgang and Bastow, Kenneth F. and Cosentino, L. Mark and Kozuka, Mutsuo and Lee, Kuo-Hsiung (2001) Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. BIOORGANIC & MEDICINAL CHEMISTRY, 9 (11). pp. 2871-2884. ISSN 0968-0896, 1464-3391
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Twenty-six simple isoquinolines and 21 benzylisoquinolines were tested for antimicrobial, antimalarial, cytotoxic, and anti-HIV activities. Some simple isoquinoline alkaloids were significantly active in each assay, and may be useful as lead compounds for developing potential chemotherapeutic agents. These compounds include 13 (antimicrobial), 25, 26, and 42 (antimalarial), 13 and 25 (cytotoxic), and 28 and 29 (anti-HIV). A quaternary nitrogen atom of isoquinolium or dihydroisoquinolinium type may contribute to enhanced potency in the first three types of activities. In contrast, anti-HIV activity was found with tetrahydroisoquinoline and 6,7-dihydroxyisoquinolium salts. (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERUM-FREE MEDIUM; PLASMODIUM-FALCIPARUM; PROTOBERBERINE ALKALOIDS; CONTINUOUS CULTIVATION; LEISHMANIA-TROPICA; METABOLISM; SALSOLINOL; PARASITES; CELLS; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2021 09:58 |
| Last Modified: | 29 Nov 2021 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40958 |
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