Kammerl, Martin C. and Nuesing, Rolf M. and Schweda, Frank and Endemann, Dierk and Stubanus, Mike and Kees, Frieder and Lackner, Karl J. and Fischereder, Michael and Kraemer, Bernhard K. (2001) Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase 2. CLINICAL PHARMACOLOGY & THERAPEUTICS, 70 (5). pp. 468-474. ISSN 0009-9236
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to examine the effects of highly selective inhibition of cyclooxygenase 2 (COX-2) with rofecoxib on the renin system during long-term stimulation and after short-term stimulation. Six healthy male volunteers received, in a randomized crossover design, a low-sodium diet for days I through 9 with or without 25 mg rofecoxib twice daily on days 5 through 9 and, in addition, 20 mg of furosemide intravenously on day 8. Plasma renin activity increased 2 to 3 times over baseline with a low-sodium diet and 5 times over baseline 30 minutes after intravenous furosemide; it was still elevated nearly 5 times on day 9. These effects were completely blocked by rofecoxib. Plasma aldosterone and urinary aldosterone concentrations basically reflected the findings with plasma renin activity. Urinary sodium excretion decreased during a low-sodium diet and increased after intravenous furosemide without being significantly affected by rofecoxib. We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCIBLE CYCLOOXYGENASE; DIFFERENTIAL REGULATION; RENAL-FUNCTION; MESSENGER-RNA; MACULA DENSA; INHIBITION; EXPRESSION; DEPLETION; ROFECOXIB; KIDNEY; |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2021 06:30 |
| Last Modified: | 30 Nov 2021 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40966 |
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