Pfeiffer, Alexandra and Boettcher, Alfred and Orso, Evelyn and Kapinsky, Michael and Nagy, Peter and Bodnar, Andrea and Spreitzer, Ingo and Liebisch, Gerhard and Drobnik, Wolfgang and Gempel, Klaus and Horn, Markus and Holmer, Stefan and Hartung, Thomas and Multhoff, Gabriele and Schuetz, Gerhard and Schindler, Hansgeorg and Ulmer, Artur J. and Heine, Holger and Stelter, Felix and Schuett, Christine and Rothe, Gregor and Szoellosi, Janos and Damjanovich, Sandor and Schmitz, Gerd (2001) Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. EUROPEAN JOURNAL OF IMMUNOLOGY, 31 (11). pp. 3153-3164. ISSN 0014-2980, 1521-4141
Full text not available from this repository. (Request a copy)Abstract
The glycosylphosphatidylinositol-anchored receptor CD14 plays a major role in the inflammatory response of monocytes to lipopolysaccharide. Here, we describe that ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co-receptors in rafts. In resting cells, CD14 was associated with CD55, the Fc gamma -receptors CD32 and CD64 and the pentaspan CD47. Ceramide further recruited the complement receptor 3 (CD11b/CD18) and CD36 into proximity of CD14. Lipopolysaccharide in addition, induced co-clustering with Toll-like receptor 4, Fc gamma -RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BACTERIAL LIPOPOLYSACCHARIDE; PLASMA-MEMBRANE; ENERGY-TRANSFER; PHAGOCYTOSIS; RETENTION; COMPLEXES; PATHWAY; CELLS; GENE; rafts; CD14; ceramide; lipopolysaccharide; receptor complexes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2021 06:47 |
| Last Modified: | 30 Nov 2021 06:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40968 |
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