Zaak, Dirk and Frimberger, Dominic and Stepp, Herbert and Wagner, Simon and Baumgartner, Reinhold and Schneede, Peter and Siebels, Michael and Knuechel, Ruth and Kriegmair, Martin and Hofstetter, Alfons (2001) Quantification of 5-aminolevulinic acid induced fluorescence improves the specificity of bladder cancer detection. JOURNAL OF UROLOGY, 166 (5). pp. 1665-1668. ISSN 0022-5347
Full text not available from this repository. (Request a copy)Abstract
Purpose: 5-Aminolevulinic acid induced fluorescence endoscopy has outstanding sensitivity for detecting early stage bladder cancer. Nevertheless, a third of the lesions that show specific fluorescence are histologically benign. We decreased the false-positive rate of 5-aminolevulinic acid induced fluorescence endoscopy by incorporating protoporphyrin IX fluorescence quantification into the standard cystoscopy procedure. Materials and Methods: In 25 cases (53 biopsies) of a history of or suspicion for bladder cancer 5-aminolevulinic acid induced fluorescence endoscopy and fluorescence image quantification were performed. For fluorescence image quantification images obtained with a target integrating color charge-coupled device camera were digitized and stored in a personal computer. Red-to-blue ratios were calculated from fluorescence positive lesions and results were correlated with hematoxylin and eosin histology. Results: Malignant fluorescence positive lesions showed significantly stronger fluorescence intensity than fluorescing lesions with benign histology. A threshold was established that decreased the false-positive rate by 30% without affecting sensitivity. Conclusions: Fluorescence image quantification is a new endoscopic method for objectively selecting multicolor fluorescence bladder lesion images for biopsy. It has the potential of eliminating human error by different surgeons with variable experience in fluorescence endoscopy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; PROTOPORPHYRIN-IX; TRANSURETHRAL RESECTION; PHOTODYNAMIC THERAPY; ENDOSCOPY; DIAGNOSIS; TUMORS; bladder; bladder neoplasms; carcinoma; transitional cell; aminolevulinic acid; fluorescence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2021 10:54 |
| Last Modified: | 30 Nov 2021 10:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40982 |
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