Kuczyk, M. A. and Bokemeyer, C. and Hartmann, J. and Schubach, J. and Walter, C. and Machtens, S. and Knuchel, R. and Kollmannsberger, C. and Jonas, U. and Serth, J. (2001) Predictive value of altered p27(Kip1) and p21(WAF/Cip1) protein expression for the clinical prognosis of patients with localized prostate cancer. ONCOLOGY REPORTS, 8 (6). pp. 1401-1407. ISSN 1021-335X
Full text not available from this repository.Abstract
The p21(WAF/Cip) and the p27(Kip1) genes have been identified as inductors of cell cycle arrest at the Gl-checkpoint. Alterations of both genes have been suggested to be involved in the development of a variety of human malignancies due to a loss of critical antiproliferative mechanisms. To evaluate the prognostic importance of these alterations for patients with clinically localized prostate cancer, in 86 specimens (T1-T4) from 86 patients undergoing radical prostatectomy at the Department of Urology at Hannover University Medical School, were investigated. The immunohistochemical expression of the p27(Kip1) and p21(WAF/Cip) protein was correlated to recurrence-free and long-term survival, age, depth of tumour infiltration, histological grade and lymph node status in these patients. After a median follow-up of 71 months (1-198 months), 14 of 20 (70%) patients (Group 1) with loss of P27(Kip1) protein expression or a relative amount of < 10% of positively stained tumour cells developed recurrent disease in contrast to 18 of 66 (27%) patients (Group 2) with retained p27(Kip1) protein expression (greater than or equal to 10% of positively stained tumour cells). The median recurrence-free survival times were 39 (4-134) months and 67 (4-198) months for patients in Groups I and 2 (p <0.01), respectively. In multivariate analysis, loss of p27(Kip1) protein expression was identified as the only independent prognostic parameter for recurrence-free survival. Univariate analysis (log-rank test) identified histological grading (p<0.01) and reactivity for p27(Kip1) (p=0.046) (<greater than or equal to>10% positivity) as prognostic factors for disease-specific long-term survival. However, during multivariate analysis none of the biological variables investigated retained independent prognostic importance regarding overall survival. Neither a low or a high expression of p21(Waf/Cip) could be correlated with the clinical prognosis of the patients following radical prostatectomy. This study confirms the independent prognostic value of decreased p27(Kip1) protein expression in patients with localized prostate cancer, while a prognostic importance of p21(Waf/Cip) in addition to established patients' and tumour characteristics like tumour stage and histological grading appears rather unlikely.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KINASE INHIBITOR P27(KIP1); DISEASE-FREE SURVIVAL; CELL LUNG-CANCER; BREAST-CANCER; CYCLIN D1; CARCINOMA; THERAPY; P21; P53; P21/WAF1/CIP1; cell cycle; prostate cancer; p21(Waf/Cip) protein; p27(Kip1) protein; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Nov 2021 13:23 |
| Last Modified: | 30 Nov 2021 13:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/40990 |
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