Täuber, Birgitt and Dobner, Thomas (2001) Molecular regulation and biological function of adenovirus early genes: the E4 ORFs. GENE, 278 (1-2). pp. 1-23. ISSN 0378-1119, 1879-0038
Full text not available from this repository. (Request a copy)Abstract
Over the past few years there have been a number of interesting advances in our understanding of the functions encoded by the adenovirus early transcription unit 4 (Ad E4). A large body of recent data demonstrates that E4 proteins encompass an unexpectedly diverse collection of functions required for efficient viral replication. E4 gene products operate through a complex network of protein interactions with key viral and cellular regulatory components involved in transcription, apoptosis, cell cycle control and DNA repair, as well as host cell factors that regulate cell signaling, posttranslational modifications and the integrity of nuclear multiprotein complexes known as nuclear bodies (NBs) or PML oncogenic domains (PODS). As understood at present, some of the lytic functions overlap with roles in oncogenic transformation of primary mammalian cells. These observations, together with findings that E4 proteins substantially affect cell toxicity and the immune response of the host have profound implications for the development of Ad vectors for gene therapy. In this article we will summarize recent findings regarding the diverse functions of E4 gene products in the context of earlier work. We will emphasize the interaction of E4 proteins with cellular and viral interaction partners, the role of these interactions for lytic virus growth and how these interactions may contribute to viral oncogenesis. Finally, we will discuss their role in Ad vector and adeno-associated virus infections. (C) 2001 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECOMBINANT ADENOASSOCIATED VIRUS; CELLULAR TRANSCRIPTION FACTOR; PROTEIN PHOSPHATASE 2A; EARLY-REGION 4; PERSISTENT TRANSGENE EXPRESSION; POLYMERASE-III TRANSCRIPTION; PRODUCTIVELY INFECTED-CELLS; E1B 55-KILODALTON PROTEIN; TUMOR-SUPPRESSOR PROTEIN; READING FRAME-1 ENCODES; DNA tumor virus; gene therapy; lyric infection; transformation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 18 May 2021 10:12 |
| Last Modified: | 18 May 2021 10:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41016 |
Actions (login required)
 |
View Item |
